ADAMTSL1

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ADAMTS-like 1
Identifiers
Symbol(s) ADAMTSL1; ADAMTSR1; MGC40193
External IDs OMIM: 609198 MGI: 1924989 HomoloGene: 64642
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 92949 77739
Ensembl ENSG00000147892 n/a
Uniprot Q8N6G6 n/a
Refseq NM_052866 (mRNA)
NP_443098 (protein)		 XM_890583 (mRNA)
XP_895676 (protein)
Location Chr 9: 18.46 - 18.71 Mb n/a
Pubmed search [1] [2]

ADAMTS-like 1, also known as ADAMTSL1, is a human gene.[1]

This gene encodes a secreted protein resembling members of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) family. This protein lacks the propeptide region and the metalloproteinase and disintegrin-like domains, which are typical of the ADAMTS family, but contains other ADAMTS domains, including the thrombospondin type 1 motif. This protein may have important functions in the extracellular matrix. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[1]

[edit] References

  1. ^ a b Entrez Gene: ADAMTSL1 ADAMTS-like 1.

[edit] Further reading

  • Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (1): 31–9. PMID 9628581. 
  • Hirohata S, Wang LW, Miyagi M, et al. (2002). "Punctin, a novel ADAMTS-like molecule, ADAMTSL-1, in extracellular matrix.". J. Biol. Chem. 277 (14): 12182–9. doi:10.1074/jbc.M109665200. PMID 11805097. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309. 
  • Hall NG, Klenotic P, Anand-Apte B, Apte SS (2004). "ADAMTSL-3/punctin-2, a novel glycoprotein in extracellular matrix related to the ADAMTS family of metalloproteases.". Matrix Biol. 22 (6): 501–10. PMID 14667842. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMID 15164053. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560. 
  • Wang LW, Dlugosz M, Somerville RP, et al. (2007). "O-fucosylation of thrombospondin type 1 repeats in ADAMTS-like-1/punctin-1 regulates secretion: implications for the ADAMTS superfamily.". J. Biol. Chem. 282 (23): 17024–31. doi:10.1074/jbc.M701065200. PMID 17395588. 
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