Allene-oxide cyclase

From Wikipedia, the free encyclopedia

In enzymology, an allene-oxide cyclase (EC 5.3.99.6) is an enzyme that catalyzes the chemical reaction

(9Z)-(13S)-12,13-epoxyoctadeca-9,11,15-trienoate (15Z)-12-oxophyto-10,15-dienoate

Hence, this enzyme has one substrate, (9Z)-(13S)-12,13-epoxyoctadeca-9,11,15-trienoate, and one product, (15Z)-12-oxophyto-10,15-dienoate.

This enzyme belongs to the family of isomerases, specifically a class of other intramolecular oxidoreductases. The systematic name of this enzyme class is (9Z)-(13S)-12,13-epoxyoctadeca-9,11,15-trienoate isomerase (cyclizing).

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 1Z8K, 1ZVC, 2BRJ, 2DIO, 2GIN, and 2Q4I.

[edit] References

• IUBMB entry for 5.3.99.6
• BRENDA references for 5.3.99.6 (Recommended.)
• PubMed references for 5.3.99.6
• PubMed Central references for 5.3.99.6
• Google Scholar references for 5.3.99.6
• Hamberg M (1988). "Biosynthesis of 12-oxo-10,15(Z)-phytodienoic acid: identification of an allene oxide cyclase". Biochem. Biophys. Res. Commun. 156: 543–50. doi:10.1016/S0006-291X(88)80876-3. PMID 3178850. 

[edit] External links

The CAS registry number for this enzyme class is 118390-59-3.

• IUBMB entry for 5.3.99.6

• KEGG entry for 5.3.99.6

• BRENDA entry for 5.3.99.6

• NiceZyme view of 5.3.99.6

• EC2PDB: PDB structures for 5.3.99.6

• PRIAM entry for 5.3.99.6

• PUMA2 entry for 5.3.99.6

• IntEnz: Integrated Enzyme entry for 5.3.99.6

• MetaCyc entry for 5.3.99.6

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0046423: allene-oxide cyclase

• AMIGO entry for GO code 0046423: allene-oxide cyclase