APPL2

From Wikipedia, the free encyclopedia

Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2

Identifiers

APPL2; DIP13B; FLJ10659

External IDs

OMIM: 606231 MGI: 2384914 HomoloGene: 10046

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• nucleus • cytoplasm • endosome membrane • membrane • NuRD complex
Biological Process:	• cell cycle • signal transduction • cell proliferation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_018171 (mRNA)
NP_060641 (protein)

NM_145220 (mRNA)
NP_660255 (protein)

Location

Chr 12: 104.09 - 104.15 Mb

Chr 10: 83.03 - 83.08 Mb

Pubmed search

[1]

[2]

Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2, also known as APPL2, is a human gene.^[1]

[edit] References

^ Entrez Gene: APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2.

[edit] Further reading

Nechamen CA, Thomas RM, Dias JA (2007). "APPL1, APPL2, Akt2 and FOXO1a interact with FSHR in a potential signaling complex.". Mol. Cell. Endocrinol. 260-262: 93-9. doi:10.1016/j.mce.2006.08.014. PMID 17030088.
Mao X, Kikani CK, Riojas RA, et al. (2006). "APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function.". Nat. Cell Biol. 8 (5): 516-23. doi:10.1038/ncb1404. PMID 16622416.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Miaczynska M, Christoforidis S, Giner A, et al. (2004). "APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment.". Cell 116 (3): 445-56. PMID 15016378.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Bonaglia MC, Giorda R, Borgatti R, et al. (2001). "Disruption of the ProSAP2 gene in a t(12;22)(q24.1;q13.3) is associated with the 22q13.3 deletion syndrome.". Am. J. Hum. Genet. 69 (2): 261-8. PMID 11431708.