CBR1

From Wikipedia, the free encyclopedia

Carbonyl reductase 1

PDB rendering based on 1wma.

Available structures: 1wma

Identifiers

Symbol(s)

CBR1; CBR; hCBR1

External IDs

OMIM: 114830 MGI: 88284 HomoloGene: 37524

Gene ontology
Molecular Function:	• carbonyl reductase (NADPH) activity • oxidoreductase activity • 15-hydroxyprostaglandin dehydrogenase (NADP+) activity • prostaglandin-E2 9-reductase activity
Cellular Component:	• cytosol
Biological Process:	• metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001757 (mRNA)
NP_001748 (protein)

NM_007620 (mRNA)
NP_031646 (protein)

Location

Chr 21: 36.36 - 36.37 Mb

Chr 16: 93.5 - 93.5 Mb

Pubmed search

[1]

[2]

Carbonyl reductase 1, also known as CBR1, is a human gene.^[1]

Carbonyl reductase is one of several monomeric, NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds. This enzyme is widely distributed in human tissues. Another carbonyl reductase gene, CRB3, lies close to this gene on chromosome 21q.^[1]

[edit] References

^ ^a ^b Entrez Gene: CBR1 carbonyl reductase 1.

[edit] Further reading

Wirth H, Wermuth B (1992). "Immunohistochemical localization of carbonyl reductase in human tissues.". J. Histochem. Cytochem. 40 (12): 1857–63. PMID 1453004.
Inazu N, Ruepp B, Wirth H, Wermuth B (1992). "Carbonyl reductase from human testis: purification and comparison with carbonyl reductase from human brain and rat testis.". Biochim. Biophys. Acta 1116 (1): 50–6. PMID 1540623.
Forrest GL, Akman S, Doroshow J, et al. (1991). "Genomic sequence and expression of a cloned human carbonyl reductase gene with daunorubicin reductase activity.". Mol. Pharmacol. 40 (4): 502–7. PMID 1921984.
Forrest GL, Akman S, Krutzik S, et al. (1990). "Induction of a human carbonyl reductase gene located on chromosome 21.". Biochim. Biophys. Acta 1048 (2-3): 149–55. PMID 2182121.
Wermuth B, Platts KL, Seidel A, Oesch F (1986). "Carbonyl reductase provides the enzymatic basis of quinone detoxication in man.". Biochem. Pharmacol. 35 (8): 1277–82. PMID 3083821.
Wermuth B, Bohren KM, Heinemann G, et al. (1988). "Human carbonyl reductase. Nucleotide sequence analysis of a cDNA and amino acid sequence of the encoded protein.". J. Biol. Chem. 263 (31): 16185–8. PMID 3141401.
Bohren KM, von Wartburg JP, Wermuth B (1987). "Kinetics of carbonyl reductase from human brain.". Biochem. J. 244 (1): 165–71. PMID 3311025.
Wermuth B (1981). "Purification and properties of an NADPH-dependent carbonyl reductase from human brain. Relationship to prostaglandin 9-ketoreductase and xenobiotic ketone reductase.". J. Biol. Chem. 256 (3): 1206–13. PMID 7005231.
Wermuth B, Mäder-Heinemann G, Ernst E (1995). "Cloning and expression of carbonyl reductase from rat testis.". Eur. J. Biochem. 228 (2): 473–9. PMID 7705364.
Krook M, Ghosh D, Strömberg R, et al. (1993). "Carboxyethyllysine in a protein: native carbonyl reductase/NADP(+)-dependent prostaglandin dehydrogenase.". Proc. Natl. Acad. Sci. U.S.A. 90 (2): 502–6. PMID 8421682.
Lemieux N, Malfoy B, Forrest GL (1993). "Human carbonyl reductase (CBR) localized to band 21q22.1 by high-resolution fluorescence in situ hybridization displays gene dosage effects in trisomy 21 cells.". Genomics 15 (1): 169–72. doi:10.1006/geno.1993.1024. PMID 8432528.
Watanabe K, Sugawara C, Ono A, et al. (1999). "Mapping of a novel human carbonyl reductase, CBR3, and ribosomal pseudogenes to human chromosome 21q22.2.". Genomics 52 (1): 95–100. doi:10.1006/geno.1998.5380. PMID 9740676.
Tinguely JN, Wermuth B (1999). "Identification of the reactive cysteine residue (Cys227) in human carbonyl reductase.". Eur. J. Biochem. 260 (1): 9–14. PMID 10091578.
Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21.". Nature 405 (6784): 311–9. doi:10.1038/35012518. PMID 10830953.
Finckh C, Atalla A, Nagel G, et al. (2001). "Expression and NNK reducing activities of carbonyl reductase and 11beta-hydroxysteroid dehydrogenase type 1 in human lung.". Chem. Biol. Interact. 130-132 (1-3): 761–73. PMID 11306092.
Balcz B, Kirchner L, Cairns N, et al. (2002). "Increased brain protein levels of carbonyl reductase and alcohol dehydrogenase in Down syndrome and Alzheimer's disease.". J. Neural Transm. Suppl. (61): 193–201. PMID 11771743.
Skálová L, Nobilis M, Szotáková B, et al. (2002). "Carbonyl reduction of the potential cytostatic drugs benfluron and 3,9-dimethoxybenfluron in human in vitro.". Biochem. Pharmacol. 64 (2): 297–305. PMID 12123751.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Cheon MS, Shim KS, Kim SH, et al. (2004). "Protein levels of genes encoded on chromosome 21 in fetal Down syndrome brain: Challenging the gene dosage effect hypothesis (Part IV).". Amino Acids 25 (1): 41–7. doi:10.1007/s00726-003-0009-9. PMID 12836057.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.