CDC34

From Wikipedia, the free encyclopedia

Cell division cycle 34 homolog (S. cerevisiae)

PDB rendering based on 2ob4.

Available structures: 2ob4

Identifiers

Symbol(s)

CDC34; E2-CDC34; UBC3; UBE2R1

External IDs

OMIM: 116948 MGI: 102657 HomoloGene: 55815

Gene ontology
Molecular Function:	• ubiquitin-protein ligase activity • ligase activity
Cellular Component:	• nucleus
Biological Process:	• G1/S transition of mitotic cell cycle • DNA replication initiation • ubiquitin cycle

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004359 (mRNA)
NP_004350 (protein)

XM_982476 (mRNA)
XP_987570 (protein)

Location

Chr 19: 0.48 - 0.49 Mb

Chr 10: 79.09 - 79.09 Mb

Pubmed search

[1]

[2]

Cell division cycle 34 homolog (S. cerevisiae), also known as CDC34, is a human gene.^[1]

The protein encoded by this gene is a member of the ubiquitin-conjugating enzyme family. Ubiquitin-conjugating enzyme catalyzes the covalent attachment of ubiquitin to other proteins. This protein is a part of the large multiprotein complex, which is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication.^[1]

[edit] References

^ ^a ^b Entrez Gene: CDC34 cell division cycle 34 homolog (S. cerevisiae).

[edit] Further reading

King RW, Deshaies RJ, Peters JM, Kirschner MW (1997). "How proteolysis drives the cell cycle.". Science 274 (5293): 1652–9. PMID 8939846.
Pagano M (1997). "Cell cycle regulation by the ubiquitin pathway.". FASEB J. 11 (13): 1067–75. PMID 9367342.
Plon SE, Leppig KA, Do HN, Groudine M (1993). "Cloning of the human homolog of the CDC34 cell cycle gene by complementation in yeast.". Proc. Natl. Acad. Sci. U.S.A. 90 (22): 10484–8. PMID 8248134.
Lisztwan J, Marti A, Sutterlüty H, et al. (1998). "Association of human CUL-1 and ubiquitin-conjugating enzyme CDC34 with the F-box protein p45(SKP2): evidence for evolutionary conservation in the subunit composition of the CDC34-SCF pathway.". EMBO J. 17 (2): 368–83. doi:10.1093/emboj/17.2.368. PMID 9430629.
Song A, Wang Q, Goebl MG, Harrington MA (1998). "Phosphorylation of nuclear MyoD is required for its rapid degradation.". Mol. Cell. Biol. 18 (9): 4994–9. PMID 9710583.
Gonen H, Bercovich B, Orian A, et al. (1999). "Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha.". J. Biol. Chem. 274 (21): 14823–30. PMID 10329681.
Pati D, Meistrich ML, Plon SE (1999). "Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis.". Mol. Cell. Biol. 19 (7): 5001–13. PMID 10373550.
Seol JH, Feldman RM, Zachariae W, et al. (1999). "Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34.". Genes Dev. 13 (12): 1614–26. PMID 10385629.
Read MA, Brownell JE, Gladysheva TB, et al. (2000). "Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha.". Mol. Cell. Biol. 20 (7): 2326–33. PMID 10713156.
Reymond F, Wirbelauer C, Krek W (2000). "Association of human ubiquitin-conjugating enzyme CDC34 with the mitotic spindle in anaphase.". J. Cell. Sci. 113 ( Pt 10): 1687–94. PMID 10769200.
Charrasse S, Carena I, Brondani V, et al. (2000). "Degradation of B-Myb by ubiquitin-mediated proteolysis: involvement of the Cdc34-SCF(p45Skp2) pathway.". Oncogene 19 (26): 2986–95. doi:10.1038/sj.onc.1203618. PMID 10871850.
Strack P, Caligiuri M, Pelletier M, et al. (2000). "SCF(beta-TRCP) and phosphorylation dependent ubiquitinationof I kappa B alpha catalyzed by Ubc3 and Ubc4.". Oncogene 19 (31): 3529–36. doi:10.1038/sj.onc.1203647. PMID 10918611.
Duan W, Sun B, Li TW, et al. (2001). "Cloning and characterization of AWP1, a novel protein that associates with serine/threonine kinase PRK1 in vivo.". Gene 256 (1-2): 113–21. PMID 11054541.
Block K, Boyer TG, Yew PR (2001). "Phosphorylation of the human ubiquitin-conjugating enzyme, CDC34, by casein kinase 2.". J. Biol. Chem. 276 (44): 41049–58. doi:10.1074/jbc.M106453200. PMID 11546811.
Wu K, Chen A, Tan P, Pan ZQ (2002). "The Nedd8-conjugated ROC1-CUL1 core ubiquitin ligase utilizes Nedd8 charged surface residues for efficient polyubiquitin chain assembly catalyzed by Cdc34.". J. Biol. Chem. 277 (1): 516–27. doi:10.1074/jbc.M108008200. PMID 11675391.
Kiernan RE, Emiliani S, Nakayama K, et al. (2001). "Interaction between cyclin T1 and SCF(SKP2) targets CDK9 for ubiquitination and degradation by the proteasome.". Mol. Cell. Biol. 21 (23): 7956–70. doi:10.1128/MCB.21.23.7956-7970.2001. PMID 11689688.
Semplici F, Meggio F, Pinna LA, Oliviero S (2002). "CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation.". Oncogene 21 (25): 3978–87. doi:10.1038/sj.onc.1205574. PMID 12037680.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.