DDOST

From Wikipedia, the free encyclopedia

Dolichyl-diphosphooligosaccharide-protein glycosyltransferase

Identifiers

DDOST; AGE-R1; KIAA0115; MGC2191; OK/SW-cl.45; OST; OST48; WBP1

External IDs

OMIM: 602202 MGI: 1194508 HomoloGene: 3821

Gene ontology
Molecular Function:	• dolichyl-diphosphooligosaccharide-protein glycotransferase activity • transferase activity
Cellular Component:	• endoplasmic reticulum • oligosaccharyl transferase complex • membrane • integral to membrane
Biological Process:	• protein amino acid N-linked glycosylation via asparagine

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005216 (mRNA)
NP_005207 (protein)

NM_007838 (mRNA)
NP_031864 (protein)

Location

Chr 1: 20.84 - 20.86 Mb

Chr 4: 137.58 - 137.58 Mb

Pubmed search

[1]

[2]

Dolichyl-diphosphooligosaccharide-protein glycosyltransferase, also known as DDOST, is a human gene.^[1]

This gene encodes a component of the oligosaccharyltransferase complex which catalyzes the transfer of high-mannose oligosaccharides to asparagine residues on nascent polypeptides in the lumen of the rough endoplasmic reticulum. The protein complex co-purifies with ribosomes. The product of this gene is also implicated in the processing of advanced glycation endproducts (AGEs), which form from non-enzymatic reactions between sugars and proteins or lipids and are associated with aging and hyperglycemia.^[1]

[edit] References

^ ^a ^b Entrez Gene: DDOST dolichyl-diphosphooligosaccharide-protein glycosyltransferase.

[edit] Further reading

Kumar V, Korza G, Heinemann FS, Ozols J (1995). "Human oligosaccharyltransferase: isolation, characterization, and the complete amino acid sequence of 50-kDa subunit.". Arch. Biochem. Biophys. 320 (2): 217-23. PMID 7625827.
Nagase T, Miyajima N, Tanaka A, et al. (1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 2 (1): 37-43. PMID 7788527.
Yamagata T, Tsuru T, Momoi MY, et al. (1998). "Genome organization of human 48-kDa oligosaccharyltransferase (DDOST).". Genomics 45 (3): 535-40. doi:10.1006/geno.1997.4966. PMID 9367678.
Stitt AW, He C, Vlassara H (1999). "Characterization of the advanced glycation end-product receptor complex in human vascular endothelial cells.". Biochem. Biophys. Res. Commun. 256 (3): 549-56. doi:10.1006/bbrc.1999.0291. PMID 10080935.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Lu C, He JC, Cai W, et al. (2004). "Advanced glycation endproduct (AGE) receptor 1 is a negative regulator of the inflammatory response to AGE in mesangial cells.". Proc. Natl. Acad. Sci. U.S.A. 101 (32): 11767-72. doi:10.1073/pnas.0401588101. PMID 15289604.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711-8. doi:10.1101/gr.2435604. PMID 15342556.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Shibatani T, David LL, McCormack AL, et al. (2005). "Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits.". Biochemistry 44 (16): 5982-92. doi:10.1021/bi047328f. PMID 15835887.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.