FGF21

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Fibroblast growth factor 21
Identifiers
Symbol(s) FGF21;
External IDs OMIM: 609436 MGI: 1861377 HomoloGene: 10428
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 26291 56636
Ensembl ENSG00000105550 ENSMUSG00000030827
Uniprot Q9NSA1 Q9JJN1
Refseq NM_019113 (mRNA)
NP_061986 (protein)		 NM_020013 (mRNA)
NP_064397 (protein)
Location Chr 19: 53.95 - 53.95 Mb Chr 7: 45.48 - 45.48 Mb
Pubmed search [1] [2]

Fibroblast growth factor 21, also known as FGF21, is a human gene.[1]

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this growth factor has not yet been determined.[1]

[edit] References

  1. ^ a b Entrez Gene: FGF21 fibroblast growth factor 21.

[edit] Further reading

  • Chen WW, Li L, Yang GY, et al. (2008). "Circulating FGF-21 levels in normal subjects and in newly diagnose patients with Type 2 diabetes mellitus.". Exp. Clin. Endocrinol. Diabetes 116 (1): 65-8. doi:10.1055/s-2007-985148. PMID 17926232. 
  • Ogawa Y, Kurosu H, Yamamoto M, et al. (2007). "BetaKlotho is required for metabolic activity of fibroblast growth factor 21.". Proc. Natl. Acad. Sci. U.S.A. 104 (18): 7432-7. doi:10.1073/pnas.0701600104. PMID 17452648. 
  • Kharitonenkov A, Wroblewski VJ, Koester A, et al. (2007). "The metabolic state of diabetic monkeys is regulated by fibroblast growth factor-21.". Endocrinology 148 (2): 774-81. doi:10.1210/en.2006-1168. PMID 17068132. 
  • Kharitonenkov A, Shiyanova TL, Koester A, et al. (2005). "FGF-21 as a novel metabolic regulator.". J. Clin. Invest. 115 (6): 1627-35. doi:10.1172/JCI23606. PMID 15902306. 
  • Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819-24. doi:10.1110/ps.04682504. PMID 15340161. 
  • Popovici C, Conchonaud F, Birnbaum D, Roubin R (2004). "Functional phylogeny relates LET-756 to fibroblast growth factor 9.". J. Biol. Chem. 279 (38): 40146-52. doi:10.1074/jbc.M405795200. PMID 15199049. 
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265-70. doi:10.1101/gr.1293003. PMID 12975309. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Nishimura T, Nakatake Y, Konishi M, Itoh N (2000). "Identification of a novel FGF, FGF-21, preferentially expressed in the liver.". Biochim. Biophys. Acta 1492 (1): 203-6. PMID 10858549. 
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