RRAGB

From Wikipedia, the free encyclopedia

Ras-related GTP binding B

Identifiers

RRAGB; RAGB; bA465E19.1

External IDs

Gene ontology
Molecular Function:	• nucleotide binding • protein binding • GTP binding
Cellular Component:	• nucleus • cytoplasm
Biological Process:	• signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006064 (mRNA)
NP_006055 (protein)

NM_001004154 (mRNA)
NP_001004154 (protein)

Location

Chr X: 55.76 - 55.8 Mb

Chr X: 148.48 - 148.51 Mb

Pubmed search

[1]

[2]

Ras-related GTP binding B, also known as RRAGB, is a human gene.^[1]

Ras-homologous GTPases constitute a large family of signal transducers that alternate between an activated, GTP-binding state and an inactivated, GDP-binding state. These proteins represent cellular switches that are operated by GTP-exchange factors and factors that stimulate their intrinsic GTPase activity. All GTPases of the Ras superfamily have in common the presence of six conserved motifs involved in GTP/GDP binding, three of which are phosphate-/magnesium-binding sites (PM1-PM3) and three of which are guanine nucleotide-binding sites (G1-G3). Transcript variants encoding distinct isoforms have been identified.^[1]

[edit] References

^ ^a ^b Entrez Gene: RRAGB Ras-related GTP binding B.

[edit] Further reading

Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325-37. doi:10.1038/nature03440. PMID 15772651.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Tomarev SI, Wistow G, Raymond V, et al. (2003). "Gene expression profile of the human trabecular meshwork: NEIBank sequence tag analysis.". Invest. Ophthalmol. Vis. Sci. 44 (6): 2588-96. PMID 12766061.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Sekiguchi T, Hirose E, Nakashima N, et al. (2001). "Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B.". J. Biol. Chem. 276 (10): 7246-57. doi:10.1074/jbc.M004389200. PMID 11073942.
Hirose E, Nakashima N, Sekiguchi T, Nishimoto T (1998). "RagA is a functional homologue of S. cerevisiae Gtr1p involved in the Ran/Gsp1-GTPase pathway.". J. Cell. Sci. 111 ( Pt 1): 11-21. PMID 9394008.
Schürmann A, Brauers A, Massmann S, et al. (1996). "Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagB1) with remote similarity to the Ras-related GTPases.". J. Biol. Chem. 270 (48): 28982-8. PMID 7499430.